00Overview
01PI
02Team
03Research
04Publications
05Science Outreach
06Contact
Fig. 01 — Isometric Overview
Institut Polytechnique de Paris

Non-Conventional
Optics for Life

— N · C · O · L —

Pioneering advanced photonics probes for health and the environment.

SAMOVAR
Telecom SudParis
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01 · Lab Head

The Principal
Investigator

Prof. Guillaume Graciani

Prof. Guillaume Graciani

Associate Professor · Institut Polytechnique de Paris

Engineer from the Institut d'Optique Graduate School, Guillaume got his PhD from Ecole Polytechnique. Working at the crossroads between fundamental optics and biology, he was amongst the 2021 recipients of Institut Polytechnique de Paris' « Best Thesis Award ».

He began his career in South Korea, where he developed new optical interferometry instruments for the study of proteins. As an Associate Professor at the Institut Polytechnique de Paris, he now combines Machine Learning, statistical optics, and computational physics to develop photonic probes for environmental, health, and biological applications.

Recent laureate of an international science communication competition organized by Nature and book author at Springer Nature, he actively works in science communication and the visual arts.

Light ScatteringInterferometryStatistical OpticsSuper-Resolution MicroscopyHeavy Metal
02 · The Group

Our Team

Caitlin Tye

Caitlin Tye

Postdoctoral Researcher

Experimental optics for the RIPPLE Pre-maturation project.

Raphël Livet

Raphël Livet

PhD Student

Optics and Deep-Learning for lensless microscopy.

Zavush Ataei

Zavush Ataei

Master's Student

Deep-Learning for computational microscopy.

Juan Diego

Juan Diego Zuniga Vargas

Master's Student

Optics for lensless microscopy. Passionate about birds and Japanese culture. Fan of Pokémon (and capybaras), and currently reading 1984.

Zige Huang

Zige Huang

Master's Student

Deep learning for FPM. Favourite language: Python. Favourite sound: electronic music, and the GPU finally starting training

Collaborators

Yaneck Gottesman

Yaneck Gottesman

Head of the Physics Department
Bernadette Dorizzi

Bernadette Dorizzi

Emeritus Professor

Alumni

Songhui "Eason" Wang

PhD Track · 2024–2026

Vasili Riabchenko

Master's Student · 2025
03 · Scientific Focus

Research Axes with a
Physics-Informed Deep Learning Backbone

Axis 01
01

3D Stochastic
Interferometry and Multi-modal Sensing

Compact and ultra-sensitive cavity enhanced photonic probe.

Axis 02
02

Lensless
Microscopy

Large field-of-view and high-resolution computational imaging.

Axis 03
03

Fourier Ptychographic
Microscopy

Computational imaging for the reconstruction of complex objects.

04 · Scientific Output

Selected Publications

Effective Communication and Single-Molecule Research

Graciani G.
Springer Nature
DOI →

Theoretical predictions for ultrasensitive sensing in three-dimensional stochastic interferometry

Graciani G., Filoche M.
Physical Review Research
DOI →

3D stochastic interferometer detects picometer deformations and minute dielectric fluctuations of its optical volume

Graciani G., Filoche M., Amblard F.
Nature Communications Physics
DOI →

Super-resolution provided by the arbitrarily strong superlinearity of the blackbody radiation

Graciani G., Amblard F.
Nature Communications
DOI →

Cavity Amplified Scattering Spectroscopy Reveals the Dynamics of Proteins and Nanoparticles in Quasi-transparent and Miniature Samples

Graciani G., King JT., Amblard F.
ACS Nano
DOI →
05 · Science Outreach

Bridging the Gap

Effective Communication and Single-Molecule Research — book cover

Effective Communication & Single-Molecule Research

This Brief explores the vital role of science communication in today's world while demystifying how research is actually conducted in modern labs today. Divided into two parts, it begins by highlighting the need for scientists to share their work with the public through accessible and nuanced communication. The first part of the book covers key concepts such as the democratization of science, the benefits of effective communication for scientists, and strategies for educators to engage diverse audiences. Readers will discover how digital amnesia affects science communication and how, rather than facts, it is the scientific method itself that needs to be taught.

The second part dives into the author's cutting-edge research, offering a behind-the-scenes look at the experimental setups and methodologies that drive scientific innovation at the frontiers of photonics and biology. From building setups with lasers and coding image processing algorithms to researching innovative drugs with machine learning, the author shares the actual process through which scientific discoveries are made in labs today.

Building on an award-winning 2024 Science in Shorts mediation content, this book is an essential resource for researchers, educators, and science communicators who seek to bridge the gap between the scientific community and the public. It is also invaluable for students and professionals in the fields of photonics and biology, providing a comprehensive understanding of the latest research techniques and their real-world applications.

Get the book →
Optical Prism from Bayeux's cathedral

Visual & Arts

Optical designer for visual artists: feasibility study and design of optical systems for modern art projects.

Collaborated with visual artists Elliot Woods, Véronique Joumard, and Cécile Pitois.

Keynote Series

For general audiences: Behind the scenes of modern science. A lecture series unpacking how research really works: how labs are funded, how peer review and publication actually functions, what scientific consensus means, and why the scientific method remains our most reliable tool for navigating an uncertain world. Designed to demystify science without dumbing it down.

For organizations: Thinking like a scientist: making decisions under uncertainty. A keynote drawing on probability paradoxes, quantum physics, and the long history of breakthrough experiments to show how science treats uncertainty not as a problem to eliminate, but as raw material for discovery and innovation. Practical takeaways for leaders, R&D teams, and decision-makers facing complex strategic choices.

Training for researchers

Why and how scientists should communicate their work. Based on my book, this training program helps researchers, PhD students and postdocs articulate their work clearly across audiences, from peers to policymakers to the general public. We cover why scientific communication matters today more than ever, and the practical methods to do it well without compromising rigor.

06 · Get in Touch

Contact Us

Address
Institut Polytechnique de Paris
19 place Marguerite Perey
91120 Palaiseau, France
We Are Recruiting
We are always looking for new team members and collaborators. Whether you are a student, post-doc, engineer, artist or just curious, try and reach out to Guillaume Graciani at: firstname.name@telecom-sudparis.eu
Values
We are committed to the inclusion of people from all backgrounds, regardless of origin, religion, sex, gender identity, sexual orientation, age, or disability.

We strive to offer all of our members an inclusive and supportive environment that prioritizes life/work balance, freedom, and collaboration.
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